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metabolism and thermoregulation
A while back, George O. wrote to the list asking how heat is generated
in endothermic animals. I was surprised that nobody responded but
also didn't feel competent to respond myself. Now, however, I can at
least point George (and anyone else interested) in the right direction
for further research.
In endothermic animals, there are proteins which "uncouple" some of
the metabolic activity of mitochondria from one of their major roles
as producers of ATP. That is, instead of building higher energy
molecules which other organelles will use to drive their normal
operations, the mitochondria burn oxygen and fatty acids for
essentially nothing more than the production of heat. (I still can't
say I know much about this, so feel free to correct me anyone -- in
fact, one of the papers I'm going to recommend below appears to
suggest an alternative mechanism).
If you want to start digging into the literature, I can recommend a
few recent articles based on an *extremely* cursory search:
Author(s): SAZANOV LA; JACKSON JB
Title: PROTON-TRANSLOCATING TRANSHYDROGENASE AND NAD-LINKED AND NADP-
LINKED ISOCITRATE DEHYDROGENASES OPERATE IN A SUBSTRATE
CYCLE WHICH CONTRIBUTES TO FINE REGULATION OF THE
TRICARBOXYLIC-ACID CYCLE ACTIVITY IN MITOCHONDRIA
Source: FEBS LETTERS V0344 N2-3 MAY 16 1994 pp. 109-116.
Author(s): DESAUTELS M; DULOS RA
Title: TEMPERATURE AND PHENYLMETHYLSULFONYL FLUORIDE SENSITIVE LOSS
OF UNCOUPLING PROTEIN IN ISOLATED BROWN ADIPOSE-TISSUE
Source: BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
V0072 N1-2 JAN-FEB 1994 pp. 1-7.
Author(s): YAMASHITA H; YAMAMOTO M; OOKAWARA T; SATO Y; UENO N; OHNO H
Title: DISCORDANCE BETWEEN THERMOGENIC ACTIVITY AND EXPRESSION OF
UNCOUPLING PROTEIN IN BROWN ADIPOSE-TISSUE OF OLD RATS
Source: JOURNALS OF GERONTOLOGY V0049 N2 MAR 1994 pp. B 54-B 59.
Author(s): TATELMAN HM; TALAN MI
Title: METABOLIC HEAT-PRODUCTION AND COLD TOLERANCE DURING COLD
STRESS OF DIFFERENT INTENSITY OF ADULT AND AGED MALE
Source: EXPERIMENTAL GERONTOLOGY V0028 N6 NOV-DEC 1993 pp. 579-584.
Author(s): DUCHAMP C; CHATONNET J; DITTMAR A; BARRE H
Title: INCREASED ROLE OF SKELETAL-MUSCLE IN THE CALORIGENIC RESPONSE
TO GLUCAGON OF COLD-ACCLIMATED DUCKLINGS
Source: AMERICAN JOURNAL OF PHYSIOLOGY V0265 N5 P2 NOV 1993 pp. R1084-
Author(s): KORTNER G; SCHILDHAUER K; PETROVA O; SCHMIDT I
Title: RAPID CHANGES IN METABOLIC COLD DEFENSE AND GDP BINDING TO
BROWN ADIPOSE-TISSUE MITOCHONDRIA OF RAT PUPS
Source: AMERICAN JOURNAL OF PHYSIOLOGY V0264 N5 P2 MAY 1993 pp. R1017-
Mickey Rowe (email@example.com)